The Effect of Trauma on Different Parameters of Coagulation Profile and Markers of Fibrinolysis.
Keywords:
Trauma, Coagulopathy, Coagulation Profile, Fibrinolysis, Acute Traumatic Coagulopathy, Prothrombin Time, Activated Partial Thromboplastin Time, Platelet Count, Fibrinogen, D-DimerSynopsis
Background: Trauma is the fifth leading cause of death in individuals between age 5 and 45 years worldwide. It will become the second leading cause by 2024. Significant blood loss can occur due to traumatic coagulopathy caused by trauma, called “Acute Traumatic Coagulopathy”. This has been scantily described in the literature. Objective: This study is aimed to study the effect of trauma on different parameters of coagulation profile and markers of fibrinolysis. Methodology :60 trauma patients between age 20 and 60 years were included. The incidence of coagulopathy was found to be 34% and overall mortality rate was 10.3 %. Association of variables like Tissue hypoperfusion, Severity of Injury, etc. with coagulopathy was proved to be statistically significant (p < 0.05). Result and conclusion: Association of the abovesaid variables with mortality was also studied and some were found to be significant. Those which were significant in univariate analysis were taken for multiple logistic regression analysis. Patients presenting with an established coagulopathy were likely to have poor outcomes, and hence must be identified as soon as possible and treated aggressively.
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May 1, 2026
Data Availability Statement
The data used and analyzed during the current study are available with the author and can be provided upon reasonable academic request.
Copyright (c) 2026 Miss Muskan Mansuri, Dr Soma Yadav (Author)
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mansuri, muskan ., & Yadav, D. S. (Eds.). (2026). The Effect of Trauma on Different Parameters of Coagulation Profile and Markers of Fibrinolysis.: Vol. BOOK 1 VOLUME 1. Research Edge and Publication. https://books.researchedgeandpublication.com/index.php/REP/catalog/book/6
